In the first game my strategy was to make sure I got a few gray resource cards and ignore the military based on the leaders I had. The first age went well. Then about halfway through the second age I realized that not only did I not have any wood, but I couldn't build the second stage of my wonder as there wasn't three wood available between my neighbours (they each had one). I never did see the double wood card that round, I think that it was likely the last card in the "dummy" player pile (that doesn't get picked up). Despite a decent science score, I was defeated 60 to 50.
|The board at the end of our first game|
|The board at the end of the second game|
Leaders are also interesting in 2-Player as each person only has one leader that the other person doesn't know; the other 3 they saw during the drafting. This means that you can start to get a sense of a person's strategy before the game begins!
I don't think that these detract from the game at all, they are just differences that I have to watch when playing 2-player, and not let affect me when we play with larger groups.